In recent years, global mergers and acquisitions (M&A) transactions have faced an increased set of regulatory challenges. Mandatory merger control approvals are proliferating and remain divergent, both in terms of their review processes and appetite for remedies in complex cases. At the same time, the rise in foreign investment review systems around the world, as national interest comes to the fore in an era of de-globalisation, adds to the regulatory burden of cross-border deal making. As the EU’s Foreign Subsidies Regulation beds down, the impact of this new regime needs to be included in the mix. This panel will discuss these regulatory challenges to global M&A deals and explore solutions for navigating the complexity.